发明名称 |
GENE DELIVERY COMPOUNDS |
摘要 |
Compounds having the structure (I) wherein R1, R2 and R3 are each independently a CO-12 substituent selected from the group consisting of: hydrogen, a heteroatom, alkyl, alkenyl, alkynyl, heteroatom substituted alkyl, heteroatom substituted alkenyl, heteroatom substituted alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl; where the heteroatom is selected from the group consisting of: N, O and S; and where (A) is a single or double bond between N and R3. Further the CO-12 substituent is linear, branched or cyclic and optionally includes a pendant moiety selected from the group consisting of: carbonyl, hydroxyl, carboxyl, amine, thiol, thioester, thioether, phosphate, alkoxy, aryl, arylalkyl, sulfonamide and alkyl halide. Further, compounds (6883, 6898, 6975, 7036, 7064 and 8496) are provided. A process is provided for activating gene transfer in a subject by administering a pharmaceutically effective amount of a gene transfer activating compound to a subject and delivering pharmaceutically effective amount of a vector containing a nucleic so that the nucleic acid is transcribed in a target cell of the subject. A process for activating gene transfer to a cell is provided. A kit for activating gene transfer is provided. |
申请公布号 |
WO02088323(A3) |
申请公布日期 |
2003.02.20 |
申请号 |
WO2002US13895 |
申请日期 |
2002.05.02 |
申请人 |
UAB RESEARCH FOUNDATION;SOUTHERN RESEARCH INSTITUTE;SORSCHER, ERIC, J.;HONG, JEONG, S.;HARRIS, JENNIFER, E.;CURLEE, KIMBERLY, V.;MADDRY, JOSEPH, A.;PARKER, WILLIAM, B.;WAUD, WILLIAM, R. |
发明人 |
SORSCHER, ERIC, J.;HONG, JEONG, S.;HARRIS, JENNIFER, E.;CURLEE, KIMBERLY, V.;MADDRY, JOSEPH, A.;PARKER, WILLIAM, B.;WAUD, WILLIAM, R. |
分类号 |
A61K31/15;A61K31/7076;A61K45/06;A61K48/00;C07D213/53 |
主分类号 |
A61K31/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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