| 摘要 |
The present invention relates to the use of irinotecan or a derivative there of for the preparation of a pharmaceutical composition for treating cancer, especially, colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer in a patient having a genotype with a variant allele which comprises a polynucleotide in accordanc e with the present invention. Preferably, a nucleotide deletion, addition and/ or substitution comprised by said polynucleotide results in an altered expressi on of variant allele compared to the corresponding wild type allele or an alter ed activity of the polypeptide encoded by the variant allele compared to the polypeptide encoded by the corresponding wild type allele. Finally, the present invention relates to a method for selecting a suitable therapy for a subject suffering from cancer, especially, colorectal cancer, cervical cance r, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreati c cancer. |
