NOVEL ALPHA ADRENERGIC AGENTS NOVEL ALPHA ADRENERGIC AGENTS

摘要

Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men (I), wherein: R1 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, cyclohexyl, C1- C6 alkyl amino, or (C1-C6 alkyl)2amino; R2 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-.sim.6 alkyl amino, or (C1-C6 alkyl)2amino; R3 is a group of the formula R4 is hydrogen or C1-C6 alkyl; R5 is hydrogen, halo, hydroxy, nitro, cyano, phenyl , trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, C1-C6 alkylamin o, or (C1-C6 alkyl)2amino; and is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-C6 alkyl amin o, or (C1-C6 alkyl)2amino; or pharmaceutically acceptable salts thereof.