发明名称 |
Humanized antibodies |
摘要 |
Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
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申请公布号 |
US2003035798(A1) |
申请公布日期 |
2003.02.20 |
申请号 |
US20010910483 |
申请日期 |
2001.07.19 |
申请人 |
FANG FANG;KOHLSTAEDT LORI;RENO JOHN |
发明人 |
FANG FANG;KOHLSTAEDT LORI;RENO JOHN |
分类号 |
C12N15/09;A61K39/395;A61P11/06;A61P31/04;A61P31/12;A61P33/06;C07K16/18;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12N15/13;C12P21/08;(IPC1-7):A61K39/395;C07K16/44;C07H21/04;C07K16/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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