发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING COX-2 ACTIVITY BY LIPOAMINO ACID METABOLISM |
摘要 |
A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence of the amino acid eicosanoid metabolite indicates the activity of the COX-2 enzyme of the subject. Preferably the amino acid eicosanoid metabolite is a PGH2-Gly or HETE-Gly metabolite. The metabolite may be detected based on metabolism of a COX-2-selective substrate. Preferably, the substrate is a lipoamino acid. More preferably, the lipoamino acid is selected from NAGly, <i>N</i>-arachidonyl-alanine, and delta -arachidonyl aminobutuyic acid. |
申请公布号 |
WO03014699(A2) |
申请公布日期 |
2003.02.20 |
申请号 |
WO2002US24864 |
申请日期 |
2002.08.06 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
MARNETT, LAWRENCE, J.;PRUSAKIEWICZ, JEFFERY, J.;KOZACK, KEVIN, R.;KINGSLEY, PHILIP, J. |
分类号 |
C12Q1/26;G01N33/574;G01N33/88 |
主分类号 |
C12Q1/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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