| 摘要 |
<p>Disclosed herein are methods for inducing apoptosis by exposing cells to an apoptic inducing amount of one or more of newly created DAG-lactone mimetics. In one embodiment of the new class of DAG compounds the new DAG-mimetic compound satisfies general formula (I) as follows:, wherein R1, R2, R3, and R4 are independently selected from the group consisting essentially of hydrogen, oxygen, nitrogen, hydroxyls, halogens, branched or unbranched, substituted or unsubstituted, aliphatic groups, heteroatom (e.g., O, S, N, hydroxyls, halogens) substituted aliphatic groups, aromatic groups, and all major functional groups. Preferably, R1 is O and R3 is a hydroxyalkyl such as CH2OH. Also preferably, R2 is an alkylidene group derived from an aldehyde and R4 is an alkyl group derived from an acid chloride. The size of the lactone ring may be varied by either increasing or decreasing the ring size. Preferably, R1, R2, R3, and R4 when comprising carbon chains or rings, comprise groups of carbon chains or rings of 12 carbon atoms or less.</p> |
