发明名称 |
Catalytic antibodies and a method of producing same |
摘要 |
The present invention is directed generally to catalytic antibodies and, more particularly, to a novel method of producing same. The method of the present invention is predicated in part on the exploitation of the products of catalysis to induce B cell mitogenesis. In a preferred embodiment, a growth factor having an ability to induce B cell mitogenesis is linked to a target antigen to which catalytic antibodies are sought. B cell mitogenesis is then dependent on the catalytic cleavage of the antigen portion of the growth factor by catalytic antibodies on the surface of B cells. The method of the present invention is useful for generating catalytic antibodies for both therapeutic and diagnostic purposes. |
申请公布号 |
US6521741(B1) |
申请公布日期 |
2003.02.18 |
申请号 |
US20000710299 |
申请日期 |
2000.11.09 |
申请人 |
FRANK KOENTGEN PTY LTD. |
发明人 |
KOENTGEN FRANK;SUESS GABRIELE MARIA;TARLINTON DAVID MATHEW;TREUTLEIN HERBERT RUDOLF |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/21;A61K38/22;A61K38/46;A61K39/00;A61K39/395;A61P37/00;A61P37/04;A61P43/00;C07K14/47;C07K14/475;C07K16/28;C07K16/42;C07K19/00;C12N9/00;C12N15/32;(IPC1-7):C07K14/00;C07K2/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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