SYNTHETIC PEPTIDE OF REGULATORY VIRUS PROTEIN R (VPR) OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND THE UTILIZATION THEREOF

摘要

The invention pertain to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr1-96), of a 47 amino acid long N- terminal (sVpr1-47), of a 49 amino acid long C-terminal fragment (sVpr48-96) as well as fragments thereof (sVpr1-20 and sVpr21-40) and further approximately 15 amin o acid long fragments of sVpr1-96. As fragments or full length products of the HIV-1 regulatory protein those products are used in biological assays, for molecular and structural characterization of Vpr and domains thereof , as well as for the development of anti-Vpr antibodies directed against Vpr peptide sequences.