发明名称 |
IMMUNRESPONSE GEGEN HPV ANTIGENE ERREGT VON ZUSAMMENSETZUNGEN DIE EIN HPV ANTIGEN UND EIN STRESSPROTEIN ENTHALTEN ODER EINEN EXPRESSIONSVEKTOR FÄHIG ZUR EXPRESSION DIESER PROTEINE |
摘要 |
<p>This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein-HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.</p> |
申请公布号 |
AT231917(T) |
申请公布日期 |
2003.02.15 |
申请号 |
AT19980910557T |
申请日期 |
1998.03.20 |
申请人 |
STRESSGEN BIOTECHNOLOGIES CORPORATION |
发明人 |
MIZZEN, LEE;CHU, RANDALL;WU, HUACHENG BILL, DR. |
分类号 |
C12N15/09;A61K35/76;A61K39/12;A61K39/385;A61K48/00;A61P31/12;C07K14/025;C07K14/35;C07K19/00;C12P21/04;(IPC1-7):C12N15/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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