METHODS AND COMPOSITIONS FOR MODULATING BRAIN DAMAGE

摘要

Methods and compositions for modulating brain damage mediated by non-NMDA ionotropic glutamate receptor antagonists are provided. Methods for inhibiting neuronal cell damage and death in the brain following an injury (e.g., ischemic/hypoxic injury) and methods for inhibiting cell damage and death in conditions such as periventricular leukomalacia, cerebral palsy, mental retardation, and neonatal stroke, are also provided. These methods generally involve treating a subject with a non-NMDA ionotropic glutamate receptor antagonist. Pharmaceutical and packaged formulations that include non-NMDA ionotropic glutamate receptor antagonists are also provided.