ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF

摘要

Compounds of structural formula (I) as herein defined are disclosed as usefu l in a method for modulating the androgen receptor in a tissue selective manne r in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including : osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreati c cancer, renal cancer, arthritis and joint repair, alone or in combination wi th other active agents. In addition, these compounds are useful as pharmaceutic al composition ingredients alone and in combination with other active agents.