| 摘要 |
Disclosed are methods of generating reconstituted cell lines and the cell lines so generated. Specifically described are methods wherein a mammalian, differentiated, diploid donor cell or nucleus is transferred into a mammalian, differentiated, diploid enucleated host cell. The donor cell or nucleus donor nucleus and the host cell can be derived from the same species or different species. The resulting nuclear transfer unit is then incubated to yield a reconstituted mammalian cell line. The cell lines can be generated to express desired human or non-human cell-surface antigens.
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