MEMBRANE FOR USE WITH IMPLANTABLE DEVICES

摘要

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer and instead forms a foreign body response (FBR) layer including: an innermost FBR layer (40) composed generally of macrophages and foreign body giant cells (41) that forms over the entire surface (48a) of the membrane (48); an intermediate FBR layer (42) composed primarily of fibroblasts (43) and fibrous matrix (44); and an outermost FBR layer (46) is loose connective granular tissue containing new blood vessels (45); wherein the innermost layer (40) is resistant to cellular attachment and is impermeable to cells and wherein the outermost layer (46) supports tissue attachment and interferes with barrier cell layer formation. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.