发明名称 |
Pharmaceutical compositions including variants of vascular endothelial cell growth factor having altered pharmacological properties |
摘要 |
Described herein are pharmaceutical compositions including vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminal heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.
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申请公布号 |
US2003032145(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
US20020200050 |
申请日期 |
2002.07.19 |
申请人 |
GENENTECH, INC. |
发明人 |
ZIONCHECK THOMAS F.;DEGUZMAN GERALYN G.;KECK RODNEY GENE |
分类号 |
A61K38/00;C07K14/52;C12N15/18;(IPC1-7):A61K38/18;C07H21/04;C07K14/475;C12P21/02;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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