| 摘要 |
The present invention aims at providing a process for producing an amic acid ester useful as an intermediate for agrochemical, easily at a low cost industrially. The present invention provides a process for producing an amic acid ester represented by the following general formula (7): (wherein A is a substituted or unsubstituted lower alkylene group or the like; R1 is a substituted or unsubstituted lower alkyl group or the like; and R3 is a hydrogen atom or a lower alkyl group), which process comprises reacting, in the presence of water, an amino acid represented by the following general formula (1): (wherein A has the same definition as given above) with a halogenated carbonic acid ester represented by the following general formula (2): (wherein R1 has the same definition as given above and X is a halogen atom) to form an amide compound represented by the following general formula (3): (wherein A and R1 have the same definitions as given above), then reacting the amide compound with a halogenated carbonic acid ester represented by the following general formula (4): (wherein R2 is a substituted or unsubstituted lower alkyl group or the like; and X is a halogen atom) to form, in the system, a mixed acid anhydride represented by the following general formula (5): (wherein A, R1 and R2 have the same definitions as given above), and reacting the mixed acid anhydride with an amine compound represented by the following general formula (6): (wherein R3 has the same definition as given above and Het is a substituted or unsubstituted heterocyclic group).
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