发明名称 |
Production of 5-alkoxy oxazoles useful as vitamin B6 intermediates comprises heating an alkyl alpha-isocyanoalkanoate ester in the presence of an auxiliary agent and simultaneously separating the product |
摘要 |
Production of 5-alkoxy oxazoles (I) comprises heating an alkyl alpha -isocyanoalkanoate ester (II) at a temperature above 80 deg C in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. Production of 5-alkoxy oxazoles of formula (I) comprises heating an alkyl alpha -isocyanoalkanoate ester of formula (II) at a temperature above 80 deg C in the presence of an auxiliary agent and simultaneously separating the product from the reaction mixture. R1 = optionally substituted 1-6C alkyl; R2 = H or optionally substituted 1-6C alkyl. An Independent claim is also included for a process for producing pyridoxine derivatives of formula (IX), comprising: (1) converting an amino acid of formula (III) to an ester of formula (IV); (2) converting (IV) to a formamido ester of formula (IV); (3) converting (IV) to (II), converting (II) to (I) as above; (4) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (5) converting (VII) to (IX) by acid treatment and deprotection. R3, R4 = protecting groups or together form a protecting group.
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申请公布号 |
DE10137480(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
DE2001137480 |
申请日期 |
2001.08.03 |
申请人 |
BASF AG |
发明人 |
RUST, HARALD;BURKART, KIRSTEN;FAUST, TILLMANN;HENKELMANN, JOCHEM;KINDLER, ALOIS;KNOLL, CHRISTIAN |
分类号 |
C07D233/70;C07D213/67;C07D263/42;(IPC1-7):C07D213/66 |
主分类号 |
C07D233/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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