MICROSCALE AFFINITY PURIFICATION SYSTEM

摘要

A microscale affinity purification system has a plurality of capillary channels (100) which begin and end in common compartments (110, 120). An introduction cross-capillary channel (130) runs across the capillary channel s (100) in a serpentine pattern (136, 138) near one end and a collection chann el (140) similarly crosses the capillaries (100) in a serpentine pattern (148, 150) near the other end. A target molecule is introduced from a reservoir (132) which binds to a desired strong ligand in a sample in the capillaries (100). The target-strong ligand comlex migrates through the capillaries (100 ), is detected at a detector (146), and collected in a collection reservoir (14 4).