发明名称 |
Kainate receptor subunit GLUR7 polymorphisms for diagnosing predisposition and for therapy of mood disorders |
摘要 |
Provided are methods for determining the predisposition of a subject to a mood disorder by determining in a biological sample of a subject, the presence of a kainate receptor subunit GluR7 allelic genotype or allelic phenotype associated with predisposition to a mood disorder. The allelic genotype is homozygosity for a thymine containing nucleotide at position 928 (928T/T) or homozygosity for a guanine containing nucleotide position 928 (928G/G). In addition, a predominant expression of one GluR7 allele over the other allele in a heterozygous individuals also predicts predisposition to a mood disorder. The present invention also includes a method of treating or preventing a mood disorder and methods for identifying a compound useful for treatment. Transgenic non-human animals that express only a particular human GluR7 allele at nucleotide position 928 also are provided as a model of a human mood disorder.
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申请公布号 |
US2003033619(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
US20010854140 |
申请日期 |
2001.05.11 |
申请人 |
SCHIFFER HANS H.;HEINEMANN STEPHEN F. |
发明人 |
SCHIFFER HANS H.;HEINEMANN STEPHEN F. |
分类号 |
C12N15/85;C12Q1/68;(IPC1-7):A01K67/027;C07H21/04 |
主分类号 |
C12N15/85 |
代理机构 |
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主权项 |
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地址 |
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