POLYVALENT VACCINE AGAINST DISEASES CAUSED BY PAPILLOMA VIRUSES, METHOD FOR THE PRODUCTION AND THE USE THEREOF

摘要

The invention relates to a vaccine against diseases caused by papilloma viruses. Said vaccine can be produced by: (a) injecting a mammal with one or more expression vectors having a DNA coding for a structure protein of papilloma viruses or a fragment thereof, wherein randomly generated heterologous sequences are used at least in part of the expression vectors in the coding DNA; (b) extracting sera from the mammals, which are then examined in order to detect the existence of antibodies against particles of different papilloma virus types; (c) identifying those structure protein clones coding for a polyvalent vaccine with the aid of the examined sera and (d) producing therefrom the vaccine. The invention also relates to a method for the production of said vaccine and to the use thereof for inoculation against diseases caused by papilloma viruses.