PROCESS FOR THE PREPARATION OF RIBAVIRIN

摘要

A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises:a) the reaction of a triazole of the formula (I) (see enclosed paper copy)with a protected ribofuranose of the formula (II) (see enclosed paper copy)b) the removal of the Pg groups and, optionally, the conversion into a carboxyamide group of the R2 group of the compound obtained of the formula (III) (see enclosed paper copy)