NOVEL IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIRUSE AS VLA-4 ANTAGONISTS

摘要

The present invention relates to novel imidazolidine derivatives of the formula (I), in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings given in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for treatin g inflammatory disease, for example rheumatoid arthritis, or allergic diseases . The compounds of the formula (I) are inhibitors of the adhesion and migratio n of leukocytes and/or antagonists of the adhesion receptor VLA-4, which belon gs to the integrin group. They are generally suitable for treating diseases whi ch are caused by, or associated with, an undesirable degree of leukocyte adhesi on and/or leukocyte migration or in which cell-cell or cell-matrix interactions , which are based on the interactions of VLA-4 receptors with their ligands, play a role. The invention furthermore relates to processes for preparing th e compounds of the formula (I), to their use and topharmaceutical preparations which comprise compounds of the formula (I).