| 摘要 |
PROBLEM TO BE SOLVED: To provide a substance P antagonist improved in activity and further reduced in adverse effect. SOLUTION: The invention relates to a pharmaceutical composition comprising a compound represented by the formula (1) [R<1> is a 1-6C alkyl; R<2> is hydrogen, a 1-6C alkyl, a halo-1-6C alkyl or phenyl; R<3> is hydrogen or a halogen; R<4> and R<5> are independently hydrogen, a 1-6C alkyl or a halo-1-6C alkyl; n is 1, 2 or 3] and a pharmaceutically acceptable salt thereof and useful as a analgesic or antiinflammatory agent or useful in treatment of diseases, disorder or harmful state caused by cardiovascular diseases, allergic diseases, angiogenesis, CNS disorder, vomiting, gastrointestinal injury, solar dermatitis, urinary incontinence or Helicobacter pylori in mammal, particularly human.
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