| 摘要 |
<p>The present invention provides an isolated human mannosyl transferase and the encoding nucleic acid. Nucleic acids and fragments thereof that correspond to the mannosyl transferase polypeptide similarly are applicable in therapeutic procedures. The invention also provides a human mannosyl transferase fusion polypeptide and a chromosome 9 fusion polypeptide, both of which result from a chromosomal 10 translocation t(9,11) (p24;q23.1) .The fusion nucleic acid sequence that encodes the human mannosyl transferase fusion polypeptide and the fusion nucleic acid sequence that encodes the chromosome 9 fusion polypeptide also are provided. The fusion proteins of the invention and their encoding nucleic acids are useful in methods provided by the present invention for diagnosing or predicting the susceptibility to bipolar disorder.</p> |
