发明名称 |
Methods of detecting and treating microsatellite-instability positive tumors using RIZ |
摘要 |
The invention provides a method of inhibiting growth of a microsatellite instability (MSI)-positive tumor. The method is practiced by introducing into an MSI-positive tumor a nucleic acid molecule encoding a RIZ1 polypeptide and expressing the RIZ1 polypeptide in the tumor in an effective amount to inhibit growth of the tumor. Also provided is a method of determining the MSI status of a tumor. The method is practiced by determining in the tumor the number of adenosine (A) nucleotides in a poly(A) tract of a RIZ nucleic acid molecule in the tumor. An abnormal number of adenosine nucleotides in a RIZ poly(A) tract indicates that the tumor is MSI-positive.
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申请公布号 |
US2003032606(A1) |
申请公布日期 |
2003.02.13 |
申请号 |
US20010024450 |
申请日期 |
2001.12.17 |
申请人 |
HUANG SHI;CHADWICK ROBERT B. |
发明人 |
HUANG SHI;CHADWICK ROBERT B. |
分类号 |
A61K48/00;C07K14/47;(IPC1-7):A61K48/00;C12Q1/68 |
主分类号 |
A61K48/00 |
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