| 发明名称 |
METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS |
| 摘要 |
The invention provides methods for generating antibiotic resistant bacteria comprising blocking mismatch repair in a bacterium to make hypermutable bacteria, contacting the bacteria with at least one antibiotic, selecting bacteria that are resistant to the antibiotic, and culturing the antibiotic resistant bacteria. The invention also provides methods of determining the genes responsible for antibiotic resistance.
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| 申请公布号 |
CA2455686(A1) |
申请公布日期 |
2003.02.13 |
| 申请号 |
CA20012455686 |
申请日期 |
2001.07.25 |
| 申请人 |
MORPHOTEK, INC. |
发明人 |
NICOLAIDES, NICHOLAS C.;KLINE, J. BRADFORD;GRASSO, LUIGI;SASS, PHILIP M. |
| 分类号 |
C12N1/00;C12N1/20;C12N15/00;C12N15/10;C12N15/74;C12Q1/02;C12Q1/20;C12Q1/68;(IPC1-7):C12Q1/02 |
主分类号 |
C12N1/00 |
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