摘要 |
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g.,to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. |
申请人 |
CURIS, INC.;RUBIN, LEE;GUICHERIT, OIVIN, M.;PRICE, STEPHEN;BOYD, EDWARD, A. |
发明人 |
RUBIN, LEE;GUICHERIT, OIVIN, M.;PRICE, STEPHEN;BOYD, EDWARD, A. |