| 发明名称 |
Process for preparing clarithromycin polymorphic forms and novel polymorph IV |
| 摘要 |
<p>The present invention relates to processes for converting clarithromycin Form 0 to clarithromycin Form II, which include slurrying clarithromycin the Form 0 in water. The present invention also relates to processes for the preparation of clarithromycin Form II by converting erythromycin A to clarithromycin and thereafter converting clarithromycin Form 0 to clarithromycin Form II by slurrying. The present invention further relates to the novel clarithromycin polymorph Form IV, a process for its preparation, pharmaceutical compositions comprising the compound, and methods of using the compound as a therapeutic agent.</p> |
| 申请公布号 |
CZ20021999(A3) |
申请公布日期 |
2003.02.12 |
| 申请号 |
CZ20020001999 |
申请日期 |
2000.12.15 |
| 申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
AVRUTOV ILYA;LIFSHITZ IGOR;BOROCHOVITZ RONEN;MASARWA BASEM;SCHWARTZ EDI |
| 分类号 |
A61K9/06;A61K9/10;A61K9/14;A61K31/7048;A61P31/04;C07H17/08;(IPC1-7):C07H17/08;A61K31/704 |
主分类号 |
A61K9/06 |
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