发明名称 |
IL-13 receptor specific chimeric proteins and uses thereof |
摘要 |
The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell bearing an IL-13 receptor. The method involves providing a chimeric molecule that comprises an effector molecule attached to a circularly permuted IL-13 ("cpIL-13") that specifically binds an IL-13 receptor and contacting the tumor cell with the chimeric molecule. The compositions include chimeric molecules comprising effector molecules such as modified Pseudomonas exotoxin attached to a cpIL-13. The invention further provides vectors encoding the chimeric molecules.
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申请公布号 |
US6518061(B1) |
申请公布日期 |
2003.02.11 |
申请号 |
US19980913370 |
申请日期 |
1998.02.17 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PURI RAJ K.;DEBINSKI WALDEMAR;PASTAN IRA;OBIRI NICHOLAS |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K51/00;A61P35/00;C07K14/21;C07K14/54;C07K16/28;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/24;(IPC1-7):C12N15/74;C12P21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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