发明名称 |
C-CAM as an angiogenesis inhibitor |
摘要 |
The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is necessary and sufficient for inhibiting angiogenesis. In particular embodiments, it relates to inhibiting hyperproliferative cell growth by administering to a cell a C-CAM1 cytoplasmic domain or an expression construct encoding a C-CAM1 cytoplasmic domain. In other embodiments, angiogenesis is inhibited by administering to a subject a C-CAM1 polypeptide or an expression construct encoding a C-CAM1 polypeptide.
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申请公布号 |
US6517828(B1) |
申请公布日期 |
2003.02.11 |
申请号 |
US20000580043 |
申请日期 |
2000.05.26 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
LIN SUE-HWA;LUO WEIPING;LOGOTHETIS CHRISTOPHER |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C07K14/705;(IPC1-7):C12N15/79 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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