| 摘要 |
This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing an aldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The aldehyde 5-oxo-1,2,4-triazine hydrazide derivative is selected from the group consisting of those with the formula:wherein R and R1 are independently selected from the group consisting of hydrogen, or alkyl wherein the alkyl group has up to 7 carbon atoms and wherein R3 is selected from the group consisting of alkyl having 1 to 7 carbon atoms, cycloalkyl having up to 7 carbon atoms, and substituted alkyl having up to 12 carbons wherein the alkyl group is substituted with one more halogen, hydroxy, amino, sulfhydryl or alkoxy having up to 10 carbon atoms, orwherein X is independently selected from hydrogen, alkyl of less than 7 carbons, halogen, amino, hydroxy and sulfhydryl and n is 4 or less, pharmaceutical salt, prodrug, metabolites and mixtures thereof. Pharmaceutical compositions comprising these compounds and their use in various treatment methods are claimed. The compounds can be used in conjunction with other chemotherapeutic agents and potentiators. The corresponding hydrazine of the formula:wherein R and R1 are independently selected from the group consisting of hydrogen, or alkyl wherein the alkyl group has up to 7 carbon atoms also have anticancer activity.
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