| 摘要 |
The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The invention further relates to a method for reducing blood cholesterol, treating atherosclerosis, treating hypercholesterolemia and/or reducing plasma lipid content of a mammal. The methods of the invention comprise orally administering to the patient a therapeutically effective amount of a polymer characterized by a polyether backbone and amino or ammonium groups pendant therefrom. The amino nitrogen atoms can be substituted by one or more substituents independently selected from among substituted and unsubstituted, normal, branched and cyclic alkyl groups, and aryl groups. When the polymer comprises pendant ammonium or quaternary ammonium groups, the polymer will be associated with a pharmaceutically acceptable anion.
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