PNEUMOLYSIN MUTANTS AND PNEUMOCOCCAL VACCINES MADE THEREFROM
摘要
Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.
申请公布号
CA2005704(C)
申请公布日期
2003.02.11
申请号
CA19892005704
申请日期
1989.12.15
申请人
PATON, JAMES C.;HANSMAN, DAVID J.;BOULNOIS, GRAHAM J.;ANDREW, PETER W.;MITCHELL, TIMOTHY J.;WALKER, JOHN A.
发明人
PATON, JAMES C.;HANSMAN, DAVID J.;BOULNOIS, GRAHAM J.;ANDREW, PETER W.;MITCHELL, TIMOTHY J.;WALKER, JOHN A.
