| 摘要 |
FIELD: medicine, biochemistry, hormones, peptides. SUBSTANCE: invention relates to peptide of the formula: where A1 means Ser; A3 means Ser or Aib; A5 means Ile; A7 means Leu or Cha; A8 means Met or Nle; A11 means Leu or Cha; A12 means Gly or Aib; A15 means Leu or Cha; A16 means Asn or Aib; A17 means Ser or Aib; A18 means Met, Nle or Acc; A19 means Glu or Aib; A21 means Val; A22 means Acc, Glu or Cha; A23 means Trp, Acc, Cha or Leu; A24 means Leu, Acc or Cha; A27 means Lys, Leu, hArg, Ac or Cha; A28 means Leu, Acc or Cha; A29 means Glu, Gln or Aib; A30 means Asp, Lys, Nle or Acc; A31 means Val, Leu, Nle, Acc or Cha; A32 means His; A33 means Asn; A34 means Phe, Tyr or Aib; each of radicals R1 and R2 means H independently each of other; and R3 means NH2 under condition that at least one of amino acid means Acc. Invention relates also to its pharmaceutically acceptable salt and these peptides are analogs of parathyroid gland hormone. Compounds show high binding degree with parathyroid hormone receptors and stimulate activity of adenylate cyclase. EFFECT: valuable medicinal and biochemical properties of peptides. 15 cl, 4 tbl |
