发明名称 |
POLYPEPTIDE REGULATING PHOSPHATE METABOLISM, CALCIUM METABOLISM, CALCIFICATION AND VITAMIN D METABOLISM AND DNAS ENCODING THE SAME |
摘要 |
DNAs encoding the following polypeptides (a), (b), (c) and (d); (a) a polypeptide comprising an amino acid sequence represented by SEQ ID NO:2 or 4; (b) a polypeptide comprising an amino acid sequence derived from an amino ac id sequence represented by SEQ ID NO:2 or 4 by the deletion, substitution or addition of one to several amino acids and having an activity of inducing hypophosphatemia, an activity of inhibiting phosphoric acid transportation, an activity of inhibiting calcification or an activity of controlling vitamin D metabolism in vivo; (c) a polypeptide comprising a partial sequence of the amino acid sequence represented by SEQ ID NO:2 wherein the partial sequence contains at least the amino acid sequence ranging from the 34th to 201st ami no acids in the above-described amino acid sequence; and (d) a polypeptide comprising a partial sequence of the amino acid sequence represented by SEQ ID NO:2 wherein the partial sequence: (i) contains at least the amino acid sequence ranging from the 34th to 201st amino acids in the above-described amino acid sequence; (ii) comprises an amino acid sequence having the deletion, substitution or addition of one to several amino acids; and (iii) has an activity of inducing hypophosphatemia, an activity of inhibiting phosphoric acid transportation,an activity of inhibiting calcification or an activity of controlling vitamin D metabolism in vivo.
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申请公布号 |
CA2418802(A1) |
申请公布日期 |
2003.02.10 |
申请号 |
CA20012418802 |
申请日期 |
2001.08.10 |
申请人 |
KIRIN BEER KABUSHIKI KAISHA |
发明人 |
FUKUMOTO, SEIJI;YAMASHITA, TAKEYOSHI;MIZUTANI, SATORU;SHIMADA, TAKASHI |
分类号 |
A61K38/00;A61K39/00;A61K48/00;A61P3/02;A61P3/14;A61P13/12;A61P19/00;A61P19/08;A61P19/10;A61P35/00;C07K14/47;C07K14/50;C07K14/705;C12P21/08;(IPC1-7):C12N15/09;C07K7/08;A61K38/17;C07K16/18;A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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