ANIMAL FEED WITH ANTIMICROBIAL REACTIVE OXYGEN SPECIES

摘要

As an alternative to an antibiotic, animal feeds contain a source of reactive oxygen species (ROS) having antimicrobial activity. Suitable ROS include hydrogen peroxide, hydroxyl radical, peroxyl radical, nitric or nitrous oxide, sulphuric acid, ozone, peroxynitrite, hypocholorus acid, persulfate, peracetic acid and percholorate. The ROS may be added to the feed or may be generated in situ , by a chemical ROS generator (perborate, persulphate, percarbonate) or enzymatic ROS generator (glucose oxidase). The ROS may be converted into a second, more potent, ROS by an ROS converter which may be an enzyme (chloroperoxidase or lactoperoxidase) or a chemical (ferrous or nitrate ions). The composition may also contain an ROS stabiliser which is an inhibitor of an enzyme which consumes or removes ROS (such as an inhibitor of catalase, superoxide dismutase or glutathione peroxidase).