摘要 |
This invention relates to a method for recombinantly producing via rescue canine distemper virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the canine distemper virus as an attenuated and/or infectious viruses. The recombinant viruses can be prepared from cDNA clones, and, accordingly, viruses having defined changes, including nucleotide/polynucleotide deletions, insertions, substitutions and rearrangements, in the genome can be obtained. |
申请人 |
AMERICAN CYANAMID COMPANY;PARKS, CHRISTOPHER, L.;SIDHU, MOHINDERJIT, S.;WALPITA, PRAMILA;KOVACS, GERALD, R.;UDEM, STEPHEN, A. |
发明人 |
PARKS, CHRISTOPHER, L.;SIDHU, MOHINDERJIT, S.;WALPITA, PRAMILA;KOVACS, GERALD, R.;UDEM, STEPHEN, A. |