PROCESS FOR THE PREPARATION OF 2-(2-(4-(BIS(4-FLUOROPHENYL)METHYL)-PIPERAZIN-1-YL)ETHOXY)ACETIC ACID DERIVATIVES OR CORRESPONDING SALT FORMS THEREOF AND INTERMEDIATES THEREFOR

摘要

The present invention relates to a process for the manufacture of 2-{2-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]ethoxy}acetic acids, amides or related derivatives, of the general formula (I) wherein: Y represents hydroxy or -NR1R2; R1 and R2 each independently represent hydrogen or C?1-4#191 alkyl; m is 1 or 2, and n is 1 or 2, as well as the non-toxic, pharmaceutically acceptable salts and mixtures thereof. The present invention concerns also a polymorphic form of efletirizine.