| 摘要 |
<p>An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR?1, or CR1¿, wherein R1 is defined herein; represents either a single or a double bond;R2 is selected from: H, halogen, R?21, OR21, SR21, COOR21,SO¿2N(R22)2, N(R22)2, , CON(R22)2,NR?22C(O)R22 or NR22C(O)NR22¿ wherein R21 and each R22 is defined herein; B is NR?3 or CR3¿, with the proviso that one of A or B is either CR?1 or CR3¿, wherein R3 is defined herein; K is N or CR4, wherein R4 is defined herein; L is N or CR5, wherein R5 has the same definition as R4; M is N or CR7, wherein R7 has the same definition as R4; Y1 is O or S; Z is N(R?6a)R6 or OR6¿, wherein R6a is H or alkyl or NR61R62 wherein R?61 and R62¿ are defined herein; and R6 is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R6 is wherein R?7 and R8¿ and Q are as defined herein; Y2 is O or S; R9 is H, (C¿1-6? alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl, aryl, Het, (C1-6)alkyl-aryl or (C1-6)alkyl-Het, all of which optionally substituted with R?90; or R9¿ is covalently bonded to either of R7 or R8 to form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.</p> |
