VIRAL POLYMERASE INHIBITORS

摘要

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is O, S, NR<1>, or CR<1>, wherein R<1> is defined herein; represents either a single or a double bond;R<2> is selected from: H, halogen, R<21>, OR<21>, SR<21>, COOR<21>,SO2N(R<22>)2, N(R<22>)2, , CON(R<22>)2,NR<22>C(O)R<22> or NR<22>C(O)NR<22> wherein R<21> and each R<22> is defined herein; B is NR<3> or CR<3>, with the proviso that one of A or B is either CR<1> or CR<3>, wherein R<3> is defined herein; K is N or CR<4>, wherein R<4> is defined herein; L is N or CR<5>, wherein R<5> has the same definition as R<4>; M is N or CR<7>, wherein R<7> has the same definition as R<4>; Y<1> is O or S; Z is N(R<6a>)R<6> or OR<6>, wherein R<6a> is H or alkyl or NR<61>R<62> wherein R<61> and R<62> are defined herein; and R<6> is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R<6> is wherein R<7> and R<8> and Q are as defined herein; Y<2> is O or S; R<9> is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl, aryl, Het, (C1-6)alkyl-aryl or (C1-6)alkyl-Het, all of which optionally substituted with R<90>; or R<9> is covalently bonded to either of R<7> or R<8> to form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.