发明名称 |
VIRAL AND NON-VIRAL VECTORS AS VEHICLES FOR DELIVERING TRANSGENES FOR TREATING BONE PATHOLOGIES |
摘要 |
The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g., a transgene) encoding a therapeutic osteoinductive factor to target cells in vivo enabling the cells to produce the osteoinductive factor at the site of the bone pathology. The delivery is achieved by a simplified method which does not require cumbersome ex vivo techniques or additional matrix or scaffolding agents. Such viral and non-viral delivery vehicles of the present invention are derived from the following nonlimiting examples: adenoviruses, adeno-associated viruses, retroviruses, herpes simplex viruses, liposomes, and plasmids. The osteoinductive factors include, but are not limited to, growth factors, cytokines, growth factor inhibitors and cytokine inhibitors. |
申请公布号 |
WO0182973(A3) |
申请公布日期 |
2003.02.06 |
申请号 |
WO2001US13493 |
申请日期 |
2001.04.27 |
申请人 |
UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
BALTZER, AXEL, W.;ROBBINS, PAUL, D.;EVANS, CHRISTOPHER, H. |
分类号 |
A61K48/00;A61P19/08;A61P19/10;C12N15/861;C12N15/867 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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