Novel genetic variants of the Chemokine Binding Protein 2 (CCBP2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CCBP2 gene. Compositions and methods for haplotyping and/or genotyping the CCBP2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.