发明名称 |
NOVEL DAMMARANE SAPOGENINS, THEIR USE AS ANTI-CANCER AGENTS, AND A PROCESS FOR PRODUCING SAME |
摘要 |
<p>This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarane sapogenin structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarane sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.</p> |
申请公布号 |
WO03010182(A1) |
申请公布日期 |
2003.02.06 |
申请号 |
WO2002CA01173 |
申请日期 |
2002.07.24 |
申请人 |
PANAGIN PHARMACEUTICALS INC.;HUANG, DONG;QI, DONG, FENG |
发明人 |
HUANG, DONG;QI, DONG, FENG |
分类号 |
A61K9/00;A61K31/575;A61K31/704;A61K36/25;A61P35/00;C07J9/00;C07J17/00;(IPC1-7):C07J17/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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