发明名称 |
Protein C or activated protein C-like molecules |
摘要 |
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and alpha1-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
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申请公布号 |
US2003027299(A1) |
申请公布日期 |
2003.02.06 |
申请号 |
US20010978917 |
申请日期 |
2001.10.17 |
申请人 |
ANDERSEN KIM VILBOUR;PEDERSEN ANDERS HJELHOLT;FRESKGAARD PER OLA |
发明人 |
ANDERSEN KIM VILBOUR;PEDERSEN ANDERS HJELHOLT;FRESKGAARD PER OLA |
分类号 |
C12N15/09;A61K38/48;A61K47/48;A61P7/02;A61P9/00;A61P9/10;A61P11/00;A61P15/00;A61P17/02;A61P31/04;A61P41/00;A61P43/00;C12N5/10;C12N9/64;C12N9/96;C12N15/57;(IPC1-7):C12N9/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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