发明名称 |
DIAGNOSING AND TREATING CANCER CELLS USING MUTANT VIRUSES |
摘要 |
The invention provides methods for the identification of genes and their encoded proteins involved in the susceptibility to proliferative disorders, including cancer, using a tumor host range mutant virus (T-HR mutant). In addition, the invention provides methods for the diagnosis of abnormally proliferating cells in a subject, using a T-HR mutant. The invention also features, T-HR mutants that can be used to kill cancer cells such as ones carrying a Sal2 alteration. Furthermore, the invention features the analysis of Sal2 nucleic acids and proteins for diagnosing and treating patients having proliferative disorders, including cancer, involving mutations in a Sal2 gene and encoded protein. Also encompassed by the invention are transgenic and knockout mice including Sal2 nucleic acids or proteins and mutants thereof.
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申请公布号 |
WO0204596(A9) |
申请公布日期 |
2003.02.06 |
申请号 |
WO2001US21354 |
申请日期 |
2001.07.05 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
BENJAMIN, THOMAS, L.;LI, DAWEI;MOK, SAMUEL, C.;CRAMER, DANIEL, W.;MA, YUPO |
分类号 |
A61K35/76;C07K14/025;C12N7/00;C12N7/08;C12Q1/68;G01N33/574;(IPC1-7):C12Q1/68;C12N5/00;C07H21/02;C07H21/04 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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地址 |
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