| 摘要 |
<p>The invention provides a hapten comprising a 6-ÄD- alpha -aminoacetamidoÜpenicillin derivative crosslinked at the alpha -amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of an intact beta -lactam ring. The invention further provides a method and a kit for detecting, or determining the quantity of, beta -lactam antibiotics, as well as, use of the aforementioned conjugate with the aforementioned antibodies for detecting, or determining the quantity of, beta -lactam antibiotics. The present invention has broad specificity across the main first generation beta -lactams and can be used to test milk and meat and the like for the presence of residual beta -lactam antibiotics. <IMAGE></p> |
