发明名称 |
USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE |
摘要 |
Compounds which are alpha-halogenoacryloyl distamycin derivatives of formula (I) wherein R<SUB>1 </SUB>is a bromine or chlorine atom; R<SUB>2 </SUB>is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies. |
申请公布号 |
EP1280527(A2) |
申请公布日期 |
2003.02.05 |
申请号 |
EP20010933856 |
申请日期 |
2001.04.19 |
申请人 |
PHARMACIA ITALIA S.P.A. |
发明人 |
GERONI, MARIA, CRISTINA, ROSA;COZZI, PAOLO;BERIA, ITALO |
分类号 |
C07D207/34;A61K31/40;A61K31/4025;A61K31/415;A61K31/4155;A61K31/4178;A61P1/00;A61P1/18;A61P11/00;A61P15/00;A61P35/00;A61P35/04;(IPC1-7):A61K31/402;A61K31/417;A61K45/06 |
主分类号 |
C07D207/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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