发明名称 |
HIV-PRODUCING CELL LINE AND USE THEREOF |
摘要 |
<p>The object of the present invention is to provide a T cell line capable of continuously producing human immunodeficiency virus (HIV) using CC chemokine receptor 5 (CCR5); and being in a state of continuously producing human immunodeficiency virus (HIV) or in a state wherein human immunodeficiency virus (HIV) is latently infecting, and a method for isolating and producing the T cell line. The present invention related to T cell line capable continuously producing human immunodeficiency virus (HIV) using cc chemokine receptor 5 (CCR5) and being in a state of continuously producing human immunodeficiency virus (HIV) is latently infecting, a method for screenings by use of the T cell line of (1) HIV resistant to an agent having an anti-HIV activity, (2) an agent having an anti-HIV activity, (3) an agent inhibiting the transition of HIV from the latent period into the proliferation period, and (4) an agent capable of eliminating HIV from T cell line; and a pharmaceutical composition comprising the agent obtained by the above screenings of (2) to (4). A T cell line of the present invention having a continuous productivity of human immunodeficiency virus (HIV) usnig CC Chemokine receptor 5 (CCR5) is useful in screening for agents or salts thereof for the treatment or prevention of diseases such as AIDS caused by HIV.</p> |
申请公布号 |
EP1281754(A1) |
申请公布日期 |
2003.02.05 |
申请号 |
EP20010930018 |
申请日期 |
2001.05.10 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
MIYAKE, HIROSHI;IIZAWA, YUJI;BABA, MASANORI |
分类号 |
A61K39/21;A61P31/18;C12N5/08;C12N7/00;G01N33/50;G01N33/569;(IPC1-7):C12N5/10 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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