发明名称 Neuropilin/growth factor complexes and uses thereof
摘要 Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B167, VEGF-C, VEGF-D or processed VEGF-B186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B167, VEGF-C, VEGF-D and/or processed VEGF-B186; and specific binding partners, e.g. antibodies, for such complexes.
申请公布号 US6515105(B1) 申请公布日期 2003.02.04
申请号 US19990421365 申请日期 1999.10.19
申请人 LICENTIA LTD.;LUDWIG INSTITUTE FOR CANCER RESEARCH 发明人 ALITALO KARI;ERIKSSON ULF;OLOFSSON BIRGITTA;MAKINEN TAIJA
分类号 C12N15/09;A61K38/22;A61K47/48;A61P9/00;A61P17/06;A61P27/02;A61P35/00;A61P43/00;C07K14/475;C07K14/52;C07K14/71;C07K14/715;C07K16/28;C07K19/00;C12N5/06;C12P21/08;C12Q1/02;(IPC1-7):C07K1/00;C07K14/00;C07K17/00;A61K38/00;A61K38/24 主分类号 C12N15/09
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