发明名称 |
Methods for the inhibition of egg production in trematodes |
摘要 |
The present invention comprises methods and compositions for use in inhibiting egg production by parasitic trematode worms comprising administering to an individual in need thereof an effective amount of an agent which transiently inhibits the influx of calcium through a cell membrane calcium channel. Inhibition of egg production in the worms ameliorates many of the symptoms and pathology related to infection by trematode related diseases, including Schistosomiasis. The methods can also effect disease transmission by reducing the number of eggs released into the environment available to continue the worm life cycle.
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申请公布号 |
US6514963(B2) |
申请公布日期 |
2003.02.04 |
申请号 |
US20010908676 |
申请日期 |
2001.07.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WALTER MARK;KURIS ARMAND |
分类号 |
A61K31/277;A61K31/44;A61K31/4422;A61K31/445;A61K31/454;A61K31/495;A61K31/554;(IPC1-7):A61K31/554;A61K39/108;A01N25/32 |
主分类号 |
A61K31/277 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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