| 发明名称 |
Method for the catalytic, symmetric disubstitution of carboxylic acid amides with grignard reagents |
| 摘要 |
The invention relates to a method for symmetrically disubstituting carboxylic acid amides on the geminal carbonyl-C-atom using grignard reagents in the presence of a metal alcoholate compound used as a catalyst and in the presence of another organometalic compound used as a co-catalyst.
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| 申请公布号 |
US6515180(B1) |
申请公布日期 |
2003.02.04 |
| 申请号 |
US20010719815 |
申请日期 |
2001.03.07 |
| 申请人 |
MERCK PATENT GESELLSCHAFT |
发明人 |
BUCHHOLZ HERWIG;WELZ-BIERMANN URS;MEIJERE ARMIN |
| 分类号 |
C07D295/02;B01J31/02;C07B61/00;C07C209/66;C07C209/68;C07C211/27;C07D295/03;(IPC1-7):C07C211/01 |
主分类号 |
C07D295/02 |
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